CATH Domain 2wm0A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family	Chitinase A

Enzyme Information

3.2.1.14

Chitinase.

based on mapping to UniProt P07254

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.

-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P07254

CHIA_SERMA

Serratia marcescens

Chitinase A

PDB Structure

PDB	2WM0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines. Macdonald, J.M., Tarling, C.A., Taylor, E.J., Dennis, R.J., Myers, D.S., Knapp, S., Davies, G.J., Withers, S.G. Angew.Chem.Int.Ed.Engl.