CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.210 | Uteroglobin |
|
1.10.210.20 |
Domain Context
CATH Clusters
| Superfamily | 1.10.210.20 |
| Functional Family | 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase |
Enzyme Information
| 1.13.11.48 |
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase.
based on mapping to UniProt O31266
3-hydroxy-2-methyl-1H-quinolin-4-one + O(2) = N-acetylanthranilate + CO.
-!- Does not contain a metal center or organic cofactor. -!- Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. -!- The enzyme from Arthrobacter sp. can also act on 3-hydroxy-4- oxoquinoline, forming N-formylanthranilate and CO (cf. EC 1.13.11.47), but more slowly.
|
UniProtKB Entries (1)
| O31266 |
HOD_PAENT
Paenarthrobacter nitroguajacolicus
1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase
|
PDB Structure
| PDB | 2WJ3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Cofactor-Independent Dioxygenation of N-Heteroaromatic Compounds at the {Alpha}/{Beta}-Hydrolase Fold.
Proc.Natl.Acad.Sci.USA
|
