CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1300 | Amidase signature (AS) enzymes |
|
3.90.1300.10 | Amidase signature (AS) domain |
Domain Context
CATH Clusters
| Superfamily | Amidase signature (AS) domain |
| Functional Family | Fatty-acid amide hydrolase 1 |
Enzyme Information
| 3.5.1.99 |
Fatty acid amide hydrolase.
based on mapping to UniProt P97612
(1) Anandamide + H(2)O = arachidonic acid + ethanolamine. (2) Oleamide + H(2)O = oleic acid + NH(3).
-!- Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia. -!- Formerly EC 3.5.1.n2.
|
UniProtKB Entries (1)
| P97612 |
FAAH1_RAT
Rattus norvegicus
Fatty-acid amide hydrolase 1
|
PDB Structure
| PDB | 2WJ2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures.
J.Am.Chem.Soc.
|
