CATH Domain 2whiA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.590	Creatine Kinase; Chain A, domain 2
	3.30.590.10	Glutamine synthetase/guanido kinase, catalytic domain

Domain Context

CATH Clusters

Superfamily	Glutamine synthetase/guanido kinase, catalytic domain
Functional Family	Glutamine synthetase

Enzyme Information

6.3.1.2

Glutamine synthetase.

based on mapping to UniProt P9WN39

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.

-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.

UniProtKB Entries (1)

P9WN39

GLN1B_MYCTU

Mycobacterium tuberculosis H37Rv

Glutamine synthetase

PDB Structure

PDB	2WHI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors. Nilsson, M.T., Krajewski, W.W., Yellagunda, S., Prabhumurthy, S., Chamarahally, G.N., Siddamadappa, C., Srinivasa, B.R., Yahiaoui, S., Larhed, M., Karlen, A., Jones, T.A., Mowbray, S.L. J.Mol.Biol.