CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
Superfamily | alpha/beta hydrolase |
Functional Family | (S)-hydroxynitrile lyase |
Enzyme Information
3.1.1.78 |
Polyneuridine-aldehyde esterase.
based on mapping to UniProt Q9SE93
Polyneuridine aldehyde + H(2)O = 16-epivellosimine + CO(2) + methanol.
-!- Following hydrolysis of this indole alkaloid ester, the carboxylic acid decarboxylates spontaneously giving the sarpagan skeleton. -!- Also acts on akuammidine aldehyde (the 16-epimer of polyneuridine aldehyde).
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UniProtKB Entries (1)
Q9SE93 |
PNAE_RAUSE
Rauvolfia serpentina
Polyneuridine-aldehyde esterase
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PDB Structure
PDB | 2WFM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural Basis and Enzymatic Mechanism of the Biosynthesis of C9- from C10-Monoterpenoid Indole Alkaloids.
Angew.Chem.Int.Ed.Engl.
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