CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Carbamate kinase

Enzyme Information

2.7.2.2
Carbamate kinase.
based on mapping to UniProt P0A2X7
ATP + NH(3) + hydrogen carbonate = ADP + carbamoyl phosphate + H(2)O.
-!- The enzyme catalyzes the reversible conversion of carbamoyl phosphate and ADP to ATP and carbamate, which hydrolyzes to ammonia and hydrogen carbonate. -!- The physiological role of the enzyme is to generate ATP.

UniProtKB Entries (1)

P0A2X7
ARCC1_ENTFA
Enterococcus faecalis V583
Carbamate kinase 1

PDB Structure

PDB 2WE4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate Binding and Catalysis in Carbamate Kinase Ascertained by Crystallographic and Site-Directed Mutagenesis Studies. Movements and Significance of a Unique Globular Subdomain of This Key Enzyme for Fermentative ATP Production in Bacteria.
Ramon-Maiques, S., Marina, A., Guinot, A., Gil-Ortiz, F., Uriarte, M., Fita, I., Rubio, V.
J.Mol.Biol.
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