CATH Domain 2waqN00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.60	Homeodomain-like

Domain Context

CATH Clusters

Superfamily	Homeodomain-like
Functional Family	DNA-directed RNA polymerases I, II, and III subunit

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt B8YB63

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

B8YB60

B8YB60_SACSH

Saccharolobus shibatae B12

DNA-directed RNA polymerase subunit H

PDB Structure

PDB	2WAQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure. Korkhin, Y., Unligil, U.M., Littlefield, O., Nelson, P.J., Stuart, D.I., Sigler, P.B., Bell, S.D., Abrescia, N.G. Plos Biol.