CATH Domain 2wabA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1110	SGNH hydrolase

Domain Context

CATH Clusters

Superfamily	SGNH hydrolase
Functional Family	Acetylxylan esterase / glucomannan deacetylase

Enzyme Information

3.2.1.4	Cellulase. based on mapping to UniProt P10477 Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. -!- Will also hydrolyze 1,4-linkages in beta-D-glucans also containing 1,3-linkages.
3.1.1.72	Acetylxylan esterase. based on mapping to UniProt P10477 Deacetylation of xylans and xylo-oligosaccharides. -!- Catalyzes the hydrolysis of acetyl groups from polymeric xylan, acetylated xylose, acetylated glucose, alpha-napthyl acetate, p-nitrophenyl acetate but not from triacetylglycerol. -!- Does not act on acetylated mannan or pectin.
3.1.1.-	Carboxylic ester hydrolases. based on mapping to UniProt P10477

UniProtKB Entries (1)

CELE_CLOTH

Hungateiclostridium thermocellum ATCC 27405

Cellulase/esterase CelE

PDB Structure

PDB	2WAB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions. Montanier, C., Money, V.A., Pires, V.M.R., Flint, J.E., Pinheiro, B.A., Goyal, A., Prates, J.A.M., Izumi, A., Stalbrand, H., Morland, C., Cartmell, A., Kolenova, K., Topakas, E., Dodson, E.J., Bolam, D.N., Davies, G.J., Fontes, C.M.G.A., Gilbert, H.J. Plos Biol.