CATH Domain 2w7xA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase Chk2

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O96017

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O96017

CHK2_HUMAN

Homo sapiens

Serine/threonine-protein kinase Chk2

PDB Structure

PDB	2W7X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019. Jobson, A.G., Lountos, G.T., Lorenzi, P.L., Llamas, J., Connelly, J., Cerna, D., Tropea, J.E., Onda, A., Zoppoli, G., Kondapaka, S., Zhang, G., Caplen, N.J., Cardellina, J.H., Yoo, S.S., Monks, A., Self, C., Waugh, D.S., Shoemaker, R.H., Pommier, Y. J.Pharmacol.Exp.Ther.