CATH Domain 2w3kA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Coagulation factor X

Enzyme Information

3.4.21.6

Coagulation factor Xa.

based on mapping to UniProt P00742

Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.

-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742

FA10_HUMAN

Homo sapiens

Coagulation factor X

PDB Structure

PDB	2W3K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action. Van Huis, C.A., Casimiro-Garcia, A., Bigge, C.F., Cody, W.L., Dudley, D.A., Filipski, K.J., Heemstra, R.J., Kohrt, J.T., Leadley, R.J.J., Narasimhan, L.S., Mcclanahan, T., Mochalkin, I., Pamment, M., Peterson, J.T., Sahasrabudhe, V., Schaum, R.P., Edmunds, J.J. Bioorg.Med.Chem.