CATH Domain 2vvnA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.379	Chitobiase; domain 2
	3.30.379.10	Chitobiase/beta-hexosaminidase domain 2-like

Domain Context

CATH Clusters

Superfamily	Chitobiase/beta-hexosaminidase domain 2-like
Functional Family

Enzyme Information

3.2.1.169

Protein O-GlcNAcase.

based on mapping to UniProt Q89ZI2

(1) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine. (2) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.

-!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.

UniProtKB Entries (1)

Q89ZI2

OGA_BACTN

Bacteroides thetaiotaomicron VPI-5482

O-GlcNAcase BT_4395

PDB Structure

PDB	2VVN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Potent Mechanism-Inspired O-Glcnacase Inhibitor that Blocks Phosphorylation of Tau in Vivo. Yuzwa, S.A., Macauley, M.S., Heinonen, J.E., Shan, X., Dennis, R.J., He, Y., Whitworth, G.E., Stubbs, K.A., Mceachern, E.J., Davies, G.J., Vocadlo, D.J. Nat.Chem.Biol.