CATH Domain 2vs6A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.420	Ricin (A subunit); domain 1
	3.40.420.10	Ricin (A subunit), domain 1

Domain Context

CATH Clusters

Superfamily	Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P09989

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P09989

RIPT_TRIKI

Trichosanthes kirilowii

Ribosome-inactivating protein alpha-trichosanthin

PDB Structure

PDB	2VS6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The C-Terminal Fragment of the Ribosomal P Protein Complexed to Trichosanthin Reveals the Interaction between the Ribosome-Inactivating Protein and the Ribosome. Too, P.H., Ma, M.K., Mak, A.N., Wong, Y.T., Tung, C.K., Zhu, G., Au, S.W., Wong, K.B., Shaw, P.C. Nucleic Acids Res.