CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Deoxynucleoside kinase |
Enzyme Information
| 2.7.1.145 |
Deoxynucleoside kinase.
based on mapping to UniProt Q9XZT6
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate.
-!- The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases (EC 2.7.1.76 and EC 2.7.1.113) in its broad specificity for all four common 2'-deoxyribonucleosides.
|
UniProtKB Entries (1)
| Q9XZT6 |
DNK_DROME
Drosophila melanogaster
Deoxynucleoside kinase
|
PDB Structure
| PDB | 2VPP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Drosophila Melanogaster Deoxyribonucleoside Kinase Activates Gemcitabine.
Biochem.Biophys.Res.Commun.
|
