CATH Domain 2vnaA01

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.180	Quinone Oxidoreductase; Chain A, domain 1
	3.90.180.10	Medium-chain alcohol dehydrogenases, catalytic domain

Superfamily	Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family	Prostaglandin reductase 2

1.3.1.48

15-oxoprostaglandin 13-reductase.

based on mapping to UniProt Q8N8N7

11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.

-!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).

PTGR2_HUMAN

Homo sapiens

Prostaglandin reductase 2

PDB	2VNA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1) Shafqat, N., Kavanagh, K., Pike, A.C.W., Muniz, J.R.C., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., von Delft, F., Opperman, U. To be Published