CATH Domain 2vhsA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Cathepsin S

Enzyme Information

3.4.22.15

Cathepsin L.

based on mapping to UniProt P07711

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07711

CATL1_HUMAN

Homo sapiens

Cathepsin L1

PDB Structure

PDB	2VHS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure and Silica Condensing Activities of Silicatein Alpha-Cathepsin L Chimeras. Fairhead, M., Johnson, K.A., Kowatz, T., Mcmahon, S.A., Carter, L.G., Oke, M., Liu, H., Naismith, J.H., Van Der Walle, C.F. Chem. Commun.