CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q6DE08
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q6DE08
AUKBA_XENLA
Xenopus laevis
Aurora kinase B-A

PDB Structure

PDB 2VGO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells.
D'Alise, A.M., Amabile, G., Iovino, M., Di Giorgio, F.P., Bartiromo, M., Sessa, F., Villa, F., Musacchio, A., Cortese, R.
Mol.Cancer Ther.