CATH Domain 2v9dA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

4.1.2.28

2-dehydro-3-deoxy-D-pentonate aldolase.

based on mapping to UniProt P75682

2-dehydro-3-deoxy-D-pentonate = pyruvate + glycolaldehyde.

4.1.2.51

2-dehydro-3-deoxy-D-gluconate aldolase.

based on mapping to UniProt P75682

2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.

-!- The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. -!- In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio. -!- It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. -!- Cf. EC 4.1.2.14.

UniProtKB Entries (1)

P75682

YAGE_ECOLI

Escherichia coli K-12

Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE

PDB Structure

PDB	2V9D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Yage, a Putative Dhdps Like Protein from Escherichia Coli K12. Manicka, S., Peleg, Y., Unger, T., Albeck, S., Dym, O., Greenblatt, H.M., Bourenkov, G., Lamzin, V., Krishnaswamy, S., Sussman, J.L. Proteins: Struct., Funct., Bioinf.