CATH Classification

Domain Context

CATH Clusters

Superfamily TolB, C-terminal domain
Functional Family

Enzyme Information

4.3.3.2
Strictosidine synthase.
based on mapping to UniProt P68175
3-alpha-(S)-strictosidine + H(2)O = tryptamine + secologanin.
-!- Catalyzes a a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine. -!- Involved in the biosynthesis of the monoterpenoid indole alkaloids.

UniProtKB Entries (1)

P68175
STSY_RAUSE
Rauvolfia serpentina
Strictosidine synthase

PDB Structure

PDB 2V91
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure Based Engineering of Strictosidine Synthase: Auxiliary for Alkaloid Libraries
Loris, E.A., Panjikar, S., Ruppert, M., Barleben, L., Unger, M., Schubel, H., Stoeckigt, J.
Chem.Biol.