CATH Domain 2v5qA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt P53350

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350

PLK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PLK1

PDB Structure

PDB	2V5Q
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin. Bandeiras, T.M., Hillig, R.C., Matias, P.M., Eberspaecher, U., Fanghanel, J., Thomaz, M., Miranda, S., Crusius, K., Putter, V., Amstutz, P., Gulotti-Georgieva, M., Binz, H.K., Holz, C., Schmitz, A.A., Lang, C., Donner, P., Egner, U., Carrondo, M.A., Muller-Tiemann, B. Acta Crystallogr. D Biol. Crystallogr.