CATH Domain 2v4mC02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10490	Glucose-6-phosphate isomerase like protein; domain 1

Domain Context

CATH Clusters

Superfamily	Glucose-6-phosphate isomerase like protein; domain 1
Functional Family	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Enzyme Information

2.6.1.16

Glutamine--fructose-6-phosphate transaminase (isomerizing).

based on mapping to UniProt Q06210

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

-!- Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination). -!- Formerly EC 5.3.1.19.

UniProtKB Entries (1)

Q06210

GFPT1_HUMAN

Homo sapiens

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

PDB Structure

PDB	2V4M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Isomerase Domain of Human Gfpt1 in Complex with Fructose 6-Phosphate Moche, M., Lehtio, L., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Svensson, S., Schueler, H., Thorsell, A.G., Tresaugues, L., Uppenberg, J., Van Den Berg, S., Welin, M., Wisniewska, M., Weigelt, J., Nordlund, P., Wikstrom, M. To be Published