CATH Domain 2v30A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Uridine monophosphate synthetase

Enzyme Information

2.4.2.10	Orotate phosphoribosyltransferase. based on mapping to UniProt P11172 Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. -!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
4.1.1.23	Orotidine-5'-phosphate decarboxylase. based on mapping to UniProt P11172 Orotidine 5'-phosphate = UMP + CO(2). -!- The enzyme from higher eukaryotes is identical with EC 2.4.2.10.

UniProtKB Entries (1)

UMPS_HUMAN

Homo sapiens

Uridine 5'-monophosphate synthase

PDB Structure

PDB	2V30
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Crystal Structure of Human Orotidine 5'-Decarboxylase Domain of Human Uridine Monophosphate Synthetase (Umps) Moche, M., Ogg, D., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nyman, T., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Welin, M., Nordlund, P. To be Published