CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.270 | Reverse transcriptase/Diguanylate cyclase domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.270 |
| Functional Family | Response regulator PleD |
Enzyme Information
| 2.7.7.65 |
Diguanylate cyclase.
based on mapping to UniProt B8GZM2
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.
-!- Can be activated by BeF3, a phosphoryl mimic, which results in dimerization. -!- Dimerization is required but is not sufficient for diguanylate- cyclase activity. -!- Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
|
UniProtKB Entries (1)
| B8GZM2 |
PLED_CAUVN
Caulobacter vibrioides NA1000
Response regulator PleD
|
PDB Structure
| PDB | 2V0N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Bef3--Modified Response Regulator Pled: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition
Structure
|
