CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.780 | Pyruvate-ferredoxin Oxidoreductase; domain 4 |
|
4.10.780.10 | Pyruvate-flavodoxin oxidoreductase, EKR domain |
Domain Context
CATH Clusters
| Superfamily | Pyruvate-flavodoxin oxidoreductase, EKR domain |
| Functional Family |
Enzyme Information
| 1.2.7.1 |
Pyruvate synthase.
based on mapping to UniProt P94692
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
-!- The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate. -!- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. -!- For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
|
UniProtKB Entries (1)
| P94692 |
PFOR_DESAF
Desulfovibrio africanus
Pyruvate:ferredoxin oxidoreductase
|
PDB Structure
| PDB | 2UZA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate.
Structure
|
