CATH Domain 2srtA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

Enzyme Information

3.4.24.17

Stromelysin 1.

based on mapping to UniProt P08254

Preferential cleavage where P1', P2' and P3' are hydrophobic residues.

-!- Extracellular endopeptidase of vertebrate tissues. -!- Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08254

MMP3_HUMAN

Homo sapiens

Stromelysin-1

PDB Structure

PDB	2SRT
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	The NMR structure of the inhibited catalytic domain of human stromelysin-1. Gooley, P.R., O'Connell, J.F., Marcy, A.I., Cuca, G.C., Salowe, S.P., Bush, B.L., Hermes, J.D., Esser, C.K., Hagmann, W.K., Springer, J.P., Johnson, B.A. Nat.Struct.Biol.