CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.150 | DNA polymerase; domain 1 |
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1.10.150.80 | HRDC domain |
Domain Context
CATH Clusters
Superfamily | HRDC domain |
Functional Family | Bloom syndrome RecQ-like helicase |
Enzyme Information
3.6.4.12 |
DNA helicase.
based on mapping to UniProt P54132
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
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UniProtKB Entries (1)
P54132 |
BLM_HUMAN
Homo sapiens
Bloom syndrome protein
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PDB Structure
PDB | 2RRD |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
Solution structure of the HRDC domain of human Bloom syndrome protein BLM
J.Biochem.
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