CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.510 | Transferase(Phosphotransferase); domain 1 | |
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | Serine/threonine-protein kinase PLK |
Enzyme Information
2.7.11.21 |
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.
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UniProtKB Entries (1)
P53350 |
PLK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK1
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PDB Structure
PDB | 2RKU |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Spodoptera |
Primary Citation |
Selectivity-determining residues in Plk1.
Chem.Biol.Drug Des.
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