CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.3.1.112 |
Anthocyanidin reductase ((2S)-flavan-3-ol-forming).
based on mapping to UniProt Q5FB34
(1) A (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH. (2) A (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH.
-!- The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway. -!- It catalyzes the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols. -!- The enzyme catalyzes sequential hydride transfers to C-2 and C-4, respectively. -!- Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers. -!- Cf. EC 1.3.1.77.
|
UniProtKB Entries (1)
| Q5FB34 |
ANRCS_VITVI
Vitis vinifera
Anthocyanidin reductase ((2S)-flavan-3-ol-forming)
|
PDB Structure
| PDB | 2RH8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and epimerase activity of anthocyanidin reductase from Vitis vinifera.
Acta Crystallogr.,Sect.D
|
