CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.90 | Alpha-Beta Complex |
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3.90.199 | Topoisomerase II; domain 5 |
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3.90.199.10 | Topoisomerase II, domain 5 |
Domain Context
CATH Clusters
Superfamily | Topoisomerase II, domain 5 |
Functional Family | DNA topoisomerase 2 |
Enzyme Information
5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P06786
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
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UniProtKB Entries (1)
P06786 |
TOP2_YEAST
Saccharomyces cerevisiae S288C
DNA topoisomerase 2
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PDB Structure
PDB | 2RGR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Saccharomyces |
Primary Citation |
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases.
Nature
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