CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.90 | Phospholipase A2 |
|
1.20.90.10 | Phospholipase A2 domain |
Domain Context
CATH Clusters
| Superfamily | Phospholipase A2 domain |
| Functional Family | Acidic phospholipase A2 |
Enzyme Information
| 3.1.1.4 |
Phospholipase A(2).
based on mapping to UniProt P60044
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
|
UniProtKB Entries (1)
| P60044 |
PA2A2_NAJSG
Naja sagittifera
Acidic phospholipase A2 2
|
PDB Structure
| PDB | 2RD4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution
To be Published
|
