CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.70 | Cathepsin B; Chain A |
|
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases |
| Functional Family | Calpain-1 catalytic subunit |
Enzyme Information
| 3.4.22.52 |
Calpain-1.
based on mapping to UniProt P97571
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.
|
UniProtKB Entries (1)
| P97571 |
CAN1_RAT
Rattus norvegicus
Calpain-1 catalytic subunit
|
PDB Structure
| PDB | 2R9C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions.
J.Med.Chem.
|
