CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.20 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.20 |
Functional Family |
Enzyme Information
6.3.4.23 |
Formate--phosphoribosylaminoimidazolecarboxamide ligase.
based on mapping to UniProt Q8U0R7
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide.
-!- This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyzes a step in the synthesis of purine nucleotides. -!- It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. -!- Cf. EC 2.1.2.3.
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UniProtKB Entries (1)
Q8U0R7 |
PURP_PYRFU
Pyrococcus furiosus DSM 3638
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
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PDB Structure
PDB | 2R87 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry
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