CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.470 | D-amino Acid Aminotransferase; Chain A, domain 1 |
|
3.30.470.20 | ATP-grasp fold, B domain |
Domain Context
CATH Clusters
| Superfamily | ATP-grasp fold, B domain |
| Functional Family |
Enzyme Information
| 6.3.4.23 |
Formate--phosphoribosylaminoimidazolecarboxamide ligase.
based on mapping to UniProt Q8U0R7
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide.
-!- This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyzes a step in the synthesis of purine nucleotides. -!- It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. -!- Cf. EC 2.1.2.3.
|
UniProtKB Entries (1)
| Q8U0R7 |
PURP_PYRFU
Pyrococcus furiosus DSM 3638
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
|
PDB Structure
| PDB | 2R85 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry
|
