CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1490 | Dna Ligase; domain 1 |
|
3.30.1490.20 | ATP-grasp fold, A domain |
Domain Context
CATH Clusters
| Superfamily | ATP-grasp fold, A domain |
| Functional Family |
Enzyme Information
| 6.3.4.23 |
Formate--phosphoribosylaminoimidazolecarboxamide ligase.
based on mapping to UniProt Q57600
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide.
-!- This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyzes a step in the synthesis of purine nucleotides. -!- It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. -!- Cf. EC 2.1.2.3.
|
UniProtKB Entries (1)
| Q57600 |
PURP_METJA
Methanocaldococcus jannaschii DSM 2661
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
|
PDB Structure
| PDB | 2R7L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry
|
