CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.270 | Reverse transcriptase/Diguanylate cyclase domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.270 |
| Functional Family |
Enzyme Information
| 3.5.4.29 |
GTP cyclohydrolase IIa.
based on mapping to UniProt Q57609
GTP + 3 H(2)O = 2-amino-5-formylamino-6-(5-phospho-D- ribosylamino)pyrimidin-4(3H)-one + 2 phosphate.
-!- This enzyme catalyzes the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N(7)-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. -!- Xanthosine 5'-triphosphate and ATP are not substrates. -!- It also catalyzes the hydrolysis of diphosphate to form two equivalents of phosphate. -!- Unlike EC 3.5.4.25, this enzyme does not release formate, but does hydrolyze the diphosphate from GTP to phosphate.
|
UniProtKB Entries (1)
| Q57609 |
GCH3_METJA
Methanocaldococcus jannaschii DSM 2661
GTP cyclohydrolase III
|
PDB Structure
| PDB | 2QV6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A New Use for a Familiar Fold: The X-ray Crystal Structure of GTP-Bound GTP Cyclohydrolase III from Methanocaldococcus jannaschii Reveals a Two Metal Ion Catalytic Mechanism
Biochemistry
|
