CATH Domain 2qu5A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Vascular endothelial growth factor receptor 2

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P35968

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968

VGFR2_HUMAN

Homo sapiens

Vascular endothelial growth factor receptor 2

PDB Structure

PDB	2QU5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Trichoplusia
Primary Citation	Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors. Potashman, M.H., Bready, J., Coxon, A., Demelfi, T.M., Dipietro, L., Doerr, N., Elbaum, D., Estrada, J., Gallant, P., Germain, J., Gu, Y., Harmange, J.C., Kaufman, S.A., Kendall, R., Kim, J.L., Kumar, G.N., Long, A.M., Neervannan, S., Patel, V.F., Polverino, A., Rose, P., Plas, S.V., Whittington, D., Zanon, R., Zhao, H. J.Med.Chem.