CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Thymidine kinase |
Enzyme Information
| 2.7.1.21 |
Thymidine kinase.
based on mapping to UniProt Q9WYN2
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.
|
UniProtKB Entries (1)
| Q9WYN2 |
KITH_THEMA
Thermotoga maritima MSB8
Thymidine kinase
|
PDB Structure
| PDB | 2QPO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure
|