CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1380 | Neutral endopeptidase; domain 2 |
|
1.10.1380.10 | Neutral endopeptidase , domain2 |
Domain Context
CATH Clusters
| Superfamily | Neutral endopeptidase , domain2 |
| Functional Family | Membrane metalloendopeptidase |
Enzyme Information
| 3.4.24.11 |
Neprilysin.
based on mapping to UniProt P08473
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
-!- A membrane-bound glycoprotein widely distributed in animal tissues. -!- Inhibited by phosphoramidon and thiorphan. -!- Belongs to peptidase family M13.
|
UniProtKB Entries (1)
| P08473 |
NEP_HUMAN
Homo sapiens
Neprilysin
|
PDB Structure
| PDB | 2QPJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Saccharomyces |
| Primary Citation |
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
Acta Crystallogr.,Sect.D
|
