CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.140 | 8 Propeller |
|
2.140.10 | Methanol Dehydrogenase; Chain A |
|
2.140.10.30 | Dipeptidylpeptidase IV, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Dipeptidylpeptidase IV, N-terminal domain |
| Functional Family | Dipeptidyl peptidase 4 |
Enzyme Information
| 3.4.14.5 |
Dipeptidyl-peptidase IV.
based on mapping to UniProt P27487
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.
|
UniProtKB Entries (1)
| P27487 |
DPP4_HUMAN
Homo sapiens
Dipeptidyl peptidase 4
|
PDB Structure
| PDB | 2QJR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine Inhibitors of Dipeptidyl Peptidase IV:
Synthesis, In Vitro, In Vivo and X-Ray Crystallographic Characterization
TO BE PUBLISHED
|
