CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family |
Enzyme Information
| 2.2.1.10 |
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.
based on mapping to UniProt Q57843
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3- dioxopropylaldehyde phosphate.
-!- The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. -!- The enzyme can also catalyze the cleavage of fructose-1,6- bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. -!- Formerly EC 4.1.2.n5.
|
UniProtKB Entries (1)
| Q57843 |
ADHS_METJA
Methanocaldococcus jannaschii DSM 2661
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
|
PDB Structure
| PDB | 2QJH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry
|
