CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1180 | Udp N-acetylglucosamine O-acyltransferase; Domain 2 |
|
1.20.1180.10 | Udp N-acetylglucosamine O-acyltransferase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Udp N-acetylglucosamine O-acyltransferase, C-terminal domain |
| Functional Family | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase |
Enzyme Information
| 2.3.1.129 |
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase.
based on mapping to UniProt P0A722
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D- glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine.
-!- Involved with EC 2.4.1.182 and EC 2.7.1.130 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
|
UniProtKB Entries (1)
| P0A722 |
LPXA_ECOLI
Escherichia coli K-12
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
|
PDB Structure
| PDB | 2QIV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa
|
