CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.930 | BirA Bifunctional Protein; domain 2 | |
3.30.930.10 | Bira Bifunctional Protein; Domain 2 |
Domain Context
CATH Clusters
Superfamily | Bira Bifunctional Protein; Domain 2 |
Functional Family |
Enzyme Information
2.3.1.181 |
Lipoyl(octanoyl) transferase.
based on mapping to UniProt Q5SLQ3
Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].
-!- The first committed step in the biosynthesis of lipoyl cofactor. -!- The lipoyl cofactor is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. -!- Examples of such lipoylated proteins include pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein). -!- Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the true substrate. -!- The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8. -!- An alternative lipoylation pathway involves EC 2.7.7.63, which can lipoylate apoproteins using exogenous lipoic acid (or its analogs).
|
UniProtKB Entries (1)
Q5SLQ3 |
LIPB_THET8
Thermus thermophilus HB8
Octanoyltransferase
|
PDB Structure
PDB | 2QHT |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structural basis of octanoic acid recognition by lipoate-protein ligase B
Proteins
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