CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family Antiviral protein I

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P84854
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P84854
RIPL2_PHYDI
Phytolacca dioica
Ribosome-inactivating protein PD-L3/PD-L4

PDB Structure

PDB 2QET
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Atomic resolution (1.1 A) structure of the ribosome-inactivating protein PD-L4 from Phytolacca dioica L. leaves
Ruggiero, A., Chambery, A., Di Maro, A., Parente, A., Berisio, R.
Proteins