1 keywords

CATH Domain 2qbrA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.190 Protein-Tyrosine Phosphatase; Chain A
Homologous Superfamily 3.90.190.10 Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P18031
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1

PDB Structure

PDB 2QBR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Wilson, D.P., Wan, Z.K., Xu, W.X., Kirincich, S.J., Follows, B.C., Joseph-McCarthy, D., Foreman, K., Moretto, A., Wu, J., Zhu, M., Binnun, E., Zhang, Y.L., Tam, M., Erbe, D.V., Tobin, J., Xu, X., Leung, L., Shilling, A., Tam, S.Y., Mansour, T.S., Lee, J.
J.Med.Chem.