CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.1
Aspartate transaminase.
based on mapping to UniProt P00509
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.

UniProtKB Entries (1)

P00509
AAT_ECOLI
Escherichia coli K-12
Aspartate aminotransferase

PDB Structure

PDB 2QB3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Liu, D., Pozharski, E., Lepore, B.W., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Biochemistry