CATH Domain 2q9mA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family	Beta-lactamase

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P05364

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P05364

AMPC_ENTCL

Enterobacter cloacae

Beta-lactamase

PDB Structure

PDB	2Q9M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	4-Substituted Trinems as Broad Spectrum beta-Lactamase Inhibitors: Structure-Based Design, Synthesis, and Biological Activity Plantan, I., Selic, L., Mesar, T., Anderluh, P.S., Oblak, M., Prezelj, A., Hesse, L., Andrejasic, M., Vilar, M., Turk, D., Kocijan, A., Prevec, T., Vilfan, G., Kocjan, D., Copar, A., Urleb, U., Solmajer, T. J.Med.Chem.