CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | cholesterol 24-hydroxylase isoform X2 |
Enzyme Information
| 1.14.14.25 |
Cholesterol 24-hydroxylase.
based on mapping to UniProt Q9Y6A2
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = (24S)- cholest-5-ene-3-beta,24-diol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- The enzyme can also produce 25-hydroxycholesterol. -!- In addition, it can further hydroxylate the product to 24,25- dihydroxycholesterol and 24,27-dihydroxycholesterol. -!- This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood- brain barrier whereas cholesterol cannot. -!- The direct electron donor to the enzyme is EC 1.6.2.4. -!- Formerly EC 1.14.13.98.
|
UniProtKB Entries (1)
| Q9Y6A2 |
CP46A_HUMAN
Homo sapiens
Cholesterol 24-hydroxylase
|
PDB Structure
| PDB | 2Q9G |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Proc.Natl.Acad.Sci.Usa
|
