CATH Domain 2q93A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.230	Creatine Amidinohydrolase
	3.90.230.10	Creatinase/methionine aminopeptidase superfamily

Domain Context

CATH Clusters

Superfamily	Creatinase/methionine aminopeptidase superfamily
Functional Family	Methionine aminopeptidase

Enzyme Information

3.4.11.18

Methionyl aminopeptidase.

based on mapping to UniProt P0AE18

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

-!- This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. -!- The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). -!- Belongs to peptidase family M24A.

UniProtKB Entries (1)

P0AE18

MAP1_ECOLI

Escherichia coli K-12

Methionine aminopeptidase

PDB Structure

PDB	2Q93
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes. Ma, Z.Q., Xie, S.X., Huang, Q.Q., Nan, F.J., Hurley, T.D., Ye, Q.Z. Bmc Struct.Biol.