1 keywords

CATH Domain 2q85A03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.78 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 1
Homologous Superfamily 3.90.78.10 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain

Domain Context

CATH Clusters

Superfamily UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
Functional Family UDP-N-acetylenolpyruvoylglucosamine reductase

Enzyme Information

1.3.1.98
UDP-N-acetylmuramate dehydrogenase.
based on mapping to UniProt P08373
UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3- O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.
-!- NADH can to a lesser extent replace NADPH. -!- Formerly EC 1.1.1.158.

UniProtKB Entries (1)

P08373
MURB_ECOLI
Escherichia coli K-12
UDP-N-acetylenolpyruvoylglucosamine reductase

PDB Structure

PDB 2Q85
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of E. Coli Mur B bound to a napthyl tetronic acid inhibitor
Mansour, T., Caulfield, C.E., Rasmussen, B., Chopra, R., Krishnamurthy, G., Morris, K.M., Svenson, K., Bard, J., Smeltzer, C., Naughton, S., Antane, S., Yang, Y., Severin, A., Quagliato, D., Petersen, P.J., Singh, G.
TO BE PUBLISHED