CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1580 | Nucleoside phosphorylase domain |
Domain Context
CATH Clusters
| Superfamily | Nucleoside phosphorylase domain |
| Functional Family |
Enzyme Information
| 2.4.2.1 |
Purine-nucleoside phosphorylase.
based on mapping to UniProt P00491
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.
|
UniProtKB Entries (1)
| P00491 |
PNPH_HUMAN
Homo sapiens
Purine nucleoside phosphorylase
|
PDB Structure
| PDB | 2Q7O |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.
J.Am.Chem.Soc.
|