CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.30 | Elongation Factor Tu (Ef-tu); domain 3 |
|
2.40.30.90 | Bacterial fluorinating enzyme like |
Domain Context
CATH Clusters
| Superfamily | Bacterial fluorinating enzyme like |
| Functional Family | Adenosyl-chloride synthase |
Enzyme Information
| 2.5.1.94 |
Adenosyl-chloride synthase.
based on mapping to UniProt A4X3Q0
S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine.
-!- This enzyme, isolated from the marine bacterium Salinispora tropica, catalyzes an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. -!- The enzyme is very similar to EC 2.5.1.63 but does not accept fluoride.
|
UniProtKB Entries (1)
| A4X3Q0 |
SALL_SALTO
Salinispora tropica CNB-440
Adenosyl-chloride synthase
|
PDB Structure
| PDB | 2Q6L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
Nat.Chem.Biol.
|
